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Complete recovery in all animals occurred within 1—1. Of the following research, the repeated-dose toxicity studies that were deemed to be most related to the chance assessment are summarized in Appendix 6. In a research performed by NTP , 5 female and male F rats have been dosed with resorcinol in deionized water via gavage at 0, High-dose females had significantly decreased absolute and relative thymus weights. No other biologically significant variations in organ weights had been observed. In distinction to these findings, Eastin et al.
The elimination was biphasic, with half-lives of 18—21 min and 8. The 14 C activity was rapidly distributed in major tissues corresponding to muscular tissues, kidneys, and liver, without indication of bioaccumulation Merker et al. Astagiudiziaria being supplied in the midst of the OECD evaluation will be offered to the IPCS in order that an addendum may be ready for consideration.


A concentration of zero. These substances have been discovered to be potent inhibitors of thyroid peroxidase or I organification. Resorcinol in addition to 2- and 5-methylresorcinol had been reported to be At an iodide concentration of zero.


Different research carried out with rats and mice gave no improve within the micronucleus formation in bone marrow cells. Bone marrow smears were prepared at 30 h, and polychromatic erythrocytes per animal were scored Gocke et al. An interim sacrifice at 15 months gave no distinction in haematology, medical chemistry, or other clinical pathology parameters and no increased incidence of neoplasms or non-neoplastic lesions. Also, at last sacrifice, there was no proof of carcinogenic exercise in males or females of both species.
Ricerca aste immobiliari agree well with the above exposure estimate based mostly on the Yeung et al.
From the scarce data obtainable, using resorcinol in hair dyes zero. The use of anti-pimples cream is taken because the situation of most concern due to the chance of continuous exposure.

In both species, there have been no opposed results on ultimate mean body weights, haematology, or medical chemistry parameters, and no chemical-related gross or microscopic lesions were noticed. In another research, rats have been exposed to zero or 0. No thyroid hormone measurements have been carried out.

No resorcinol-associated macroscopic findings, organ weight, or antagonistic microscopic target organ results had been observed in the F zero and F 1 parental animals. The F 0 and F 1 females continued to obtain the resorcinol throughout mating, gestation, and lactation and thru the day of euthanasia for research design, see Appendix 7. There were no F 0 and F 1 parental resorcinol-associated deaths or scientific findings through the weekly detailed bodily examinations. In controls and the high-dose group, a qualitative histopathological analysis of the brain forebrain, midbrain, and hindbrain was also performed for the aforementioned animals RTF, There were no adverse effects concerning reproductive performance, mortality, and body or organ weights.
https://www.instapaper.com/read/1287175517 of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The impact of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are not any epidemiological knowledge relevant to the carcinogenicity of resorcinol in humans and that the evidence of its carcinogenicity in animals is insufficient; thus, resorcinol is not classifiable as to its carcinogenicity to people. JECFA assessed the hazards from using resorcinol as a food flavouring agent and concluded that this use is of no security concern. Overall, the research are not enough for a statistical extrapolation technique in accordance with the EU Technical Guidance Document EC, a.
Animals have been maintained for several months with periodic sacrifices Flickinger, The animals had been then examined weekly for 10 additional weeks. Sacrificed animals confirmed brown-dyed abdomen partitions and filling of stomach and small intestine with a darkish-brown to orange substance. These findings were not noted in survivors.


For the benthic and terrestrial compartments, the obtainable toxicity data cannot be thought to be enough for a quantitative threat characterization. However, these compartments are less related for resorcinol, due to marginal releases and emissions to these compartments as well as a really low potential for adsorption of resorcinol to natural matter.